A Dynamic Substrate is Required for MhuD-Catalyzed Degradation…
The noncanonical heme oxygenase MhuD from Mycobacterium tuberculosis binds a heme substrate that adopts a dynamic equilibrium between planar and out-of-plane ruffled conformations. MhuD degrades this substrate to an uncommon mycobilin product through successive monooxygenation and dioxygenation…